Cellular Targeting in Autoimmunity
نویسندگان
چکیده
منابع مشابه
Targeting IL-17 in autoimmunity and inflammation.
The discovery of two distinct subsets of helper T cells, IFN-γ-producing Th1 cells and IL-4-producing Th2 cells, about three decades ago enabled us to understand the immunopathology of cell-mediated and allergic inflammatory diseases in humans. The observation that T cell-mediated experimental autoimmune diseases can be induced in mice lacking Th1 and Th2 cell responses prompted many immunologi...
متن کاملTargeting IL-33 in Autoimmunity and Inflammation
Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines. Whereas IL-1 is processed and released by live immune cells in response to infection or other triggers, IL-33 is mostly released as a danger signal (“alarmin”) from damaged cells. IL-33 may also be processed and released from activated mast cells (MCs) with subsequent autocrine and paracrine actions. IL-33 augments the stimulatory ...
متن کاملTargeting autoreactive germinal centers to curb autoimmunity
Autoimmune diseases have been on the rise in the past decades, particularly in Western societies [1]. Today, autoimmune disorders rank third on the list of most prevalent causes of morbidity and mortality in the Western world. Many autoimmune conditions, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are characterized by the presence of affinity-matured, class-switche...
متن کاملLupus autoimmunity altered by cellular methylation metabolism.
Modifications of both DNA and protein by methylation are key factors in normal T and B cell immune responses as well as in the development of autoimmune disease. For example, the failure to maintain the methylation status of CpG dinucleotides in DNA triggers T cell autoreactivity. Methylated proteins are known targets of autoimmunity, including the symmetrical dimethylarginine residues of SmD1 ...
متن کاملAbsence of cellular responses to a putative autoantigen in onchocercal chorioretinopathy. Cellular autoimmunity in onchocercal chorioretinopathy.
PURPOSE Onchocerciasis is a major cause of blindness in the developing world. An autoimmune pathogenesis for onchocercal chorioretinopathy was proposed after the identification of a recombinant Onchocerca volvulus antigen (designated Ov39) demonstrated immunologic crossreactivity with a component of the retinal pigment epithelium and other ocular tissues. The aim of this study was to determine ...
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ژورنال
عنوان ژورنال: Current Allergy and Asthma Reports
سال: 2012
ISSN: 1529-7322,1534-6315
DOI: 10.1007/s11882-012-0307-y